The production of pyrogenic exotoxins by group A streptococci

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Nonspecific T-lymphocyte mitogenesis by pyrogenic exotoxins from group A streptococci and Staphylococcus aureus.

Group A streptococcal pyrogenic exotoxins types A, B, and C and staphylococcal pyrogenic exotoxin were shown to be potent nonspecific T-lymphocyte mitogens. Adherent cell populations did not significantly affect the nonspecific mitogenicity.

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Ganglioside and monosaccharide inhibition of nonspecific lymphocyte mitogenicity by group A streptococcal pyrogenic exotoxins.

Group A streptococcal pyrogenic exotoxins (SPE) types A, B, and C are potent nonspecific lymphocyte mitogens. The mitogenicity of these exotoxins was inhibited by gangliosides and sialic acid, whereas concanavalin A was unaffected. The capacity of both concanavalin A and SPE-A to stimulate lymphocytes was suppressed by alpha-methyl-D-mannopyranoside. Galactose reduced the activity of SPE-C. The...

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Staphylococcal scarlet fever: role of pyrogenic exotoxins.

Staphylococcal pyrogenic exotoxin (PE) types A and B were tested for their role in production of a scarlatiniform rash. The PEs elicited minimal skin reactions after intracutaneous injection into animals not presensitized to the toxins. In contrast, erythematous injection into animals not presensitized to the toxins. In contrast, erythematous and edematous rashes were produced after administrat...

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Bacteriocine Production by Group a Streptococci

I t has been known for many years t ha t some strains of Escherichia coli, Bacillus megaterium, and Group D streptococci secrete substances called colicines, or bacteriocines, which inhibi t the growth of o ther strains of closely related microorganisms (1-6). In 1949 Sherwood and his coworkers (7) reported observations on the inhibitory action of certain strains of be ta hemolyt ic streptococc...

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ژورنال

عنوان ژورنال: Journal of Hygiene

سال: 1985

ISSN: 0022-1724

DOI: 10.1017/s0022172400062276